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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21 are 6
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5112
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.2 percent target mRNA inhibition
    22253019
    SM5113
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    95.34 percent target mRNA inhibition
    22253019
    SM5115
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    95.54 percent target mRNA inhibition
    22253019
    SM5292
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    94.18 percent target mRNA inhibition
    22253019
    SM5293
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    92.8 percent target mRNA inhibition
    22253019
    SM5295
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.47 percent target mRNA inhibition
    22253019